In 1982, he made his acting introduction by playing the person named Rajali in the Tamil-language activity show film Sangili, a revamp of the 1976 Hindi film Kalicharan.

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Prabhu Ganesan co-featured as Shekar in the 1988 Tamil-language film Manasukkul Mathappu and this job won him the Cinema Express Award for “Best Actor – Tamil”.

Close by Khushbu, he co-featured as Chinna Thambi in the 1991 Tamil-language heartfelt show film Chinna Thambi. For this presentation, he sacked the Tamil Nadu State Film Award for “Best Actor”.

He played the nominal person in the 1994 Tamil-language activity dramatization film Rajakumaran. It became Prabhu Ganesan’s 100th film.

In 2002, he showed up as Ramakrishnan, a rich money manager in Ooty who possesses a promoting organization and tea bequests, in the Tamil-language parody film Charlie Chaplin.

This job won him the Tamil Nadu State Film Special Award for “Best Actor” while he was additionally designated at the 2002 Filmfare Awards South.